Transition-metal-catalyzed C-H Functionalization
Heterocycle Synthesis
Total Synthesis of Natural Products
Synthesis and Biological Evaluation of Noble Scaffolds
학력
(Ph.D.) 2003-2006, Sungkyunkwan University, College of Pharmacy
약력/경력
2007-2009, University of Texas at Austin, Department of Chemistry, Postdoctoral Fellow
2009-2012, University of Ulsan, Department of Chemistry, Assistant Professor
2012-2012, Kyung Hee University, Department of Pharmacy, Assistant Professor
2012-2013, Sungkyunkwan University, School of Pharmacy, Assistant Professor
2013-present, Sungkyunkwan University, School of Pharmacy, Associate Professor
학술지 논문
(2022)
Cobalt(II)-Catalyzed C-H Alkylation of N-Heterocycles with 1,4-Dihydropyridines.
ACS CATALYSIS.
12,
24
(2021)
Synthesis of pi-Extended Heterocycles via Rh(III)-Catalyzed Oxidative Annulation of 5-Aryl Pyrazinones with Alkynes.
JOURNAL OF ORGANIC CHEMISTRY.
86,
23
(2021)
Synthesis of spirosuccinimides via annulative cyclization between N-aryl indazolols and maleimides under rhodium(iii) catalysis.
CHEMICAL COMMUNICATIONS.
57,
83
(2021)
Synthesis of (2H)-Indazoles and Dihydrocinnolinones through Annulation of Azobenzenes with Vinylene Carbonate under Rh(III) Catalysis.
ORGANIC LETTERS.
23,
14
(2021)
Catalyst-Free One-Pot Multi-Component Synthesis of 2-Substituted Quinazolin-4-carboxamides from 2-Aminophenyl-2-oxoacetamides, Aldehydes, and Ammonium Acetate.
CHEMISTRYSELECT.
6,
22
(2021)
Site-Selective C8-Alkylation of Quinoline N-Oxides with Maleimides under Rh(III) Catalysis.
JOURNAL OF ORGANIC CHEMISTRY.
86,
11
(2021)
A novel synthetic microtubule inhibitor exerts antiproliferative effects in multidrug resistant cancer cells and cancer stem cells.
SCIENTIFIC REPORTS.
11,
1
(2021)
Ruthenium(II)-Catalyzed C-H/N-H Carbonylative Cyclization of 2-Aryl Quinazolinones with Isocyanates as CO Surrogates.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY.
42,
3
(2021)
Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor.
BIOORGANIC MEDICINAL CHEMISTRY LETTERS.
37,
37
(2021)
Direct Integration of Phthalazinone and Succinimide Scaffolds via Rh(III)-Catalyzed C-H Functionalization.
ASIAN JOURNAL OF ORGANIC CHEMISTRY.
10,
1
(2021)
C-H Methylation of Iminoamido Heterocycles with Sulfur Ylides**.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
60,
1
(2020)
Ru(ii)-Catalyzed C-H addition and oxidative cyclization of 2-aryl quinazolinones with activated aldehydes.
ORGANIC & BIOMOLECULAR CHEMISTRY.
18,
47
(2020)
Site-Selective C-H Amidation of 2-Aryl Quinazolinones Using Nitrene Surrogates.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY.
2020,
46
(2020)
C2-Selective C-H Methylation of Heterocyclic N-Oxides with Sulfonium Ylides.
ORGANIC LETTERS.
22,
22
(2020)
Ratiometric Turn-On Fluorophore Displacement Ensembles for Nitroaromatic Explosives Detection.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY.
142,
46
(2020)
Biological Evaluation of Oxindole Derivative as a Novel Anticancer Agent against Human Kidney Carcinoma Cells.
BIOMOLECULES.
10,
9
(2020)
Transition-Metal-Free and Site-Selective Selenylation of Heterocyclic N-Oxides in Anisole as a Green Solvent.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY.
2020,
31
(2020)
Total Synthesis of (+/-)-Liphagal via Organic-Redox-Driven Palladium-Catalyzed Hydroxybenzofuran Formation.
JOURNAL OF ORGANIC CHEMISTRY.
85,
14
(2020)
Phthalazinone-Assisted C-H Amidation Using Dioxazolones Under Rh(III) Catalysis.
JOURNAL OF ORGANIC CHEMISTRY.
85,
11
(2020)
EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats.
CELLS.
9,
5
특허/프로그램
COX-2 억제제를 유효성분으로 포함하는 소염진통 예방 또는 치료용 정제 조성물.
10-2018-0113181.
20210514.
대한민국
포스포늄일리드를 이용한 디아진-N-옥사이드의 위치선택적 알킬화 방법.
10-2019-0122995.
20210319.
대한민국
케타이드 화합물, 이의 제조방법, 및 이의 당뇨병 치료용도.
10-2018-0006151.
20210219.
대한민국
피리딘을 함유하는 유기 화합물의 ortho 위치에 알킬을 도입하는 방법.
10-2019-0042046.
20210217.
대한민국
4중 연속 고리 화합물의 신규한 제조방법.
10-2019-0111753.
20210119.
대한민국
피모자이드의 항암제 병용요법.
10-2019-0042935.
20210111.
대한민국
신규 2-아실 아크리딘 유도체, 이의 제조방법, 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 조성물.
10-2018-0102326.
20200422.
대한민국
퀴놀린-8-일메탄아민, 이의 제조방법 및 이를 유효성분으로 포함하는 암예방 및 치료용 조성물.
10-2017-0154137.
20200406.
대한민국
펜치논 에이 및 그 유도체의 제조방법과 이를 유효성분으로 포함하는 항염증 조성물.
10-2017-0131446.
20191127.
대한민국
텔미사르탄을 포함하는 고체 분산체 및 이의 제조방법.
10-2016-0117255.
20191107.
대한민국
1-아미노인단 및 이의 제조방법.
10-2018-0001194.
20191011.
대한민국
피롤로인돌리디온 유도체, 및 이의 제조방법.
10-2017-0049254.
20191010.
대한민국
이리듐 촉매를 이용한 아미노벤즈알데히드의 제조방법, 이를 이용한 화합물 및 이를 유효성분으로 포함하는 염증성 질환의 예방 또는 치료용 약학적 조성물.
10-2017-0096491.
20190712.
대한민국
Oxindoles derivatives, preparation method thereof and pharmaceutical compositions for the prevention or treatment of cancer containing the same as an active ingredient.
US20180339965 A1.
20190618.
미국
신규 스파이로아이소인돌리논 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 암 예방 및 치료용 조성물.
10-2016-0169438.
20190422.
대한민국
인돌 유도체를 유효성분으로 포함하는 당뇨병 예방 또는 치료용 약학적 조성물.
10-2019-0009010.
20190422.
대한민국
아조벤젠과 이중결합을 이용한 2,3-이중치환 인돌 유도체의 제조방법, 이를 이용한 화합물, 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물.
10-2017-0097610.
20190418.
대한민국
옥시인돌 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 조성물.
10-2017-0065385.
20190306.
대한민국
신규 인돌 유도체, 이의 제조방법, 및 이를 유효성분으로 포함하는 당뇨병 예방 또는 치료용 약학적 조성물.
10-2018-0136227.
20190218.
대한민국
로듐 촉매를 이용한 아미드화 인돌린의 제조방법, 이를 이용한 화합물 및 이를 유효성분으로 포함하는 암 예방 및 치료용 약학적 조성물.
10-2016-0123108.
20181011.
대한민국
수상/공훈
Handok Pharmaceutical Company, Young Scientist Award (2013)
Pharmaceutical Society of Korea, Young Scientist Award (2014)
학술회의논문
(2020)
Direct C-H Functionalization of N-Heterocycles Enabled byPhosphonium and Sulfonium Ylides.
1st AASP Young Scientist Conference 2020.
인도네시아
(2020)
C-H Functionalization of 2-Aryl Quinazolinones under Transition-Metal-Catalyst.
2020 제22회 한국유기합성학회 학술대회(추계학술대회) 및 정기총회.
대한민국
(2020)
Direct Methylation of N-Heterocycles using Sulfoxonium Ylides in Aqueous Media.
2020 제22회 한국유기합성학회 학술대회(추계학술대회) 및 정기총회.
대한민국
(2020)
Ruthenium-Catalyzed Synthesis of Indazolophathalazinones via C-H Hydroxyalkylation of N-Aryl Phthalazinone.
2020 제22회 한국유기합성학회 학술대회(추계학술대회) 및 정기총회.
대한민국
(2019)
Tandem C-H Allylation and [3+2] Dipolar Cycloaddition Under Ruthenium(II) Catalysis.
124th General Meeting of the Korean Chemical Society.
대한민국
(2019)
Catalytic C-H Allylation: Access to Bioactive Scaffolds.
12th AFMC International Medicinal Chemistry Symposium.
튀르키예
(2019)
Site-Selective C-H Alkylation of Heterocyclic N-Oxides Using Phosphonium Ylides.
12th AFMC International Medicinal Chemistry Symposium.
튀르키예
(2019)
C-H Functionalization: From Morita-Baylis-Hillman (MBH) Adducts to Allylic Acetals.
20th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis.
독일
(2019)
Diastereoselective C-H Activation of Aldimines Under Rh (III) Catalysis.
제15회 대한약학회 약품화학분과학회 워크샵.
대한민국
(2019)
Dual Role of Anthranils as Directing Groups and Amination Surroagtes: Synthesis of Acridines.
제15회 대한약학회 약품화학분과학회 워크샵.
대한민국
(2018)
Synthesis and Cytotoxic Evaluation of N-Aroylureas Under Rh(III)-Catalyst via C-H Functionalization.
2018년 18회 한국유기합성학회 학술대회 및 정기총회.
대한민국
(2018)
Annulation reaction of azobenzenes with sulfoxonium ylides under Rh(III) catalysis.
2018 Fall International Convention of The Pharmaceutical Society of Korea.
대한민국
(2018)
Synthesis and cytotoxic evaluation of quinolin-8-ylmethanamines.
2018 Fall International Convention of The Pharmaceutical Society of Korea.
대한민국
(2018)
Annulation Reaction of Azobenzenes via Rh(III)-Catalyzed C-H Activation.
4th International Symposium on C-H Activation.
일본
(2018)
C-H Aminocarbonylation of N-(Hetero)aryl-7-azaindoles under Ru(II) Catalysis.
4th International Symposium on C-H Activation.
일본
(2018)
Dual Role of Anthranils as Amination and Transient Directing Group Sources: Synthesis of 2-Acyl Acridines.
4th International Symposium on C-H Activation.
일본
(2017)
Synthesis and cytotoxic evaluation of N-aroylureas under Rh(III)-catalyzed C-H functionalization.
2017 Fall International Convention of The Pharmaceutical Society of Korea.
대한민국
(2017)
C(sp3)-H Allkylation of 8-Methylquinolines with Allylic Alcohols Under Rhodium(III)-Catalysis.
2017 한국유기합성학회 추계학술대회 및 정기총회.
대한민국
(2017)
Cross-Coupling Reaction of 8-Methylquinolines with Maleimides
under Rhodium Catalysis.
26th ISHC Congress.
독일
(2017)
Ru(II)- or Rh(III)-Catalyzed Grignard-Type C−H Additions of Indolic Scaffolds
with Activated Aldehydes and Ketones.
26th ISHC Congress.
독일